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Posted by1 month ago
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Crossposted by1 month ago
Posted by1 month ago
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Crossposted by1 month ago
Posted by1 month ago
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Posted by10 days ago

JYNNEOS the small pox and monkey pox vaccine can be used for pre-exposure prophylaxis. Close contacts of patients with monkey pox can receive JYNNEIS within 4 days of exposure to prevent disease or within 14 days to reduce disease severity.

Tecoviramat (TPOXX) is an antiviral approved for smallpox but a 5-year placebo-controlled trial for monkey pox PALM007 won’t start til later this summer, via the WHO.

TEcoviramat has a cool mechanism of action (interferes with an envelope protein in all orthopox viruses so the Virginia cannot exit infected cells). This mechanism also means there is a low resistance barrier however. Lab studies that change the amino acids in the viral envelope substantially reduce Tecoviramat’s activity.

So a back-up therapeutic like a monoclonal antibody can be useful. The Vanderbilt Vaccine Center have generated monoclonal antibodies against Ortho pox viruses including MPX since 2016.

Monoclonal antibodies would provide quick, long-lasting effective protection particularly in immune suppressed patients but also in the vaccine resistant.

Downside of monoclonals is cost and expense and slow production, both of which can be mitigated with INO’s dMAb tech.

WHO is probably not able to fund this. DARPA should be interested because it would provide the added benefit of protection / therapeutic in the event of a small pox biologic attack.

INO should pursue the monoclonal discussion with DARPA. Obviously they can’t self-fund, and obviously the INO-4800 Booster studies are being done by non-Inovio personnel (WHO, Advaccine). So the idea that INO is too busy to address MPX doesn’t hold water. Time for Shea to put some value back on the table.

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